TweetHas anyone taken both and noticed a difference? I wanna use it but not sure which one to use. I hear alot of people say the difference is non-existant!

Reminds me of the egg debate, with or without the yolk!

TweetBass's article in the thread goes into more detail about R-ALA
This is what I wrote in this thread: https://fitnessgeared.com/forum/showt...highlight=rala

"I had to read this about 4 times, but this is what I got from it.

This article reinforces what Bass wrote/posted. But it is contrary to what I found on most sites selling R-ALA.

On supplement retail sites they are explicitly saying that S-ALA is useless. According to this that is incorrect. While not as effective as R-ALA, there are benefits. This suggest buying just a regular ALA with a 50:50 ratio might be rational with regard to the money saved and benefits received.


"The racemic mixture of the antioxidant alpha-lipoic acid (ALA) enhances insulin-stimulated glucose metabolism in insulin-resistant humans and animals. We determined the individual effects of the pure R-(+) and S-(-) enantiomers of ALA on glucose metabolism in skeletal muscle of an animal model of insulin resistance, hyperinsulinemia, and dyslipidemia: the obese Zucker (fa/fa) rat. Obese rats were treated intraperitoneally acutely (100 mg/kg body wt for 1 h) or chronically [10 days with 30 mg/kg of R-(+)-ALA or 50 mg/kg of S-(-)-ALA]. Glucose transport [2-deoxyglucose (2-DG) uptake], glycogen synthesis, and glucose oxidation were determined in the epitrochlearis muscles in the absence or presence of insulin (13.3 nM). Acutely, R-(+)-ALA increased insulin-mediated 2-DG-uptake by 64% (P < 0.05), whereas S-(-)-ALA had no significant effect. Although chronic R-(+)-ALA treatment significantly reduced plasma insulin (17%) and free fatty acids (FFA; 35%) relative to vehicle-treated obese animals, S-(-)-ALA treatment further increased insulin (15%) and had no effect on FFA. Insulin-stimulated 2-DG uptake was increased by 65% by chronic R-(+)-ALA treatment, whereas S-(-)-ALA administration resulted in only a 29% improvement. Chronic R-(+)-ALA treatment elicited a 26% increase in insulin-stimulated glycogen synthesis and a 33% enhancement of insulin-stimulated glucose oxidation. No significant increase in these parameters was observed after S-(-)-ALA treatment. Glucose transporter (GLUT-4) protein was unchanged after chronic R-(+)-ALA treatment but was reduced to 81 +/- 6% of obese control with S-(-)-ALA treatment. Therefore, chronic parenteral treatment with the antioxidant ALA enhances insulin-stimulated glucose transport and non-oxidative and oxidative glucose metabolism in insulin-resistant rat skeletal muscle, with the R-(+) enantiomer being much more effective than the S-(-) enantiomer. "

https://ajpendo.physiology.org/cgi/c...ract/273/1/E185

https://www.google.com/search?hl=en&...lipoic+acid+pdf"

TweetPersonally I thought ALA was better. I could tell a difference. Especially when I was using creatine as well.