I am not sure exactly what you are referring to as liver detox but if you talking about things like milk thistle, NAC, TUDCA (Tauroursodeoxycholic acid), Polyenylphosphatidylcholine. There is a lot of evidence showing that these help protect and support liver function in many ways.. Everyone responds differently to everything from food to vitamins to prescription drugs. There is no cure all medicine or vitamin. If the user feels better after taking a vitamin supplement or prescription drug, or placebo then great because the end result is what matters. How the user gets there is not the main focus the end result is. To have doubts or be skeptical about something is fine but to say that something isn't possible or that something is flat out ineffective is just being close minded. Many things are debateable in life but that doesn't mean either side is best for everyone. The liver is a very complex organ. We do have blood tests to moniter liver function but even these are not 100% accurate as to how the liver is functioning. There is reason to believe that many liver support supplements do have a positive effect on the liver. If you don't believe so fine you are entitled to your opinion but it doesn't mean your beliefs fit everyone nor should you assume they should. For every study you can pull up showing these ingredients were ineffective there are at least an equal number showing they are effective at supporting healthy liver function. There is no need for negativity there is no one clear cut answer.