Tweeti'm in 5th week of 6 running the TB500 at 5mgs twice per week. the PT that i've been working with post surgery for my torn rotator cuff has been very surprised and happy with the ROM and the continual increase in range each visit .she said they like to see a 3-4 degree increase in the range of motion. i've been averaging 6-10 degrees each visit to the point that this past monday the chief PT did my assessment and said dude, you're doing so great that we only need to see you once a week instead of twice and cancelled my weds appointment. i see the surgeon for 12 week follow up dec 21 and PT is sure with the great process made i'll get green light to start strengthening with weights to be on my way back to the gym full time. not sure if more would be better but 5mg 2x week has been instrumental along with the steady 4-5 times day stretching and performing the prescribed rehab exercises. IMHO this stuff is akin to the rule of thumb in all bodybuilding, just because 1 is good doesn't translate into 10 is better.