Treating mice with GW501516 (10 mg/kg/d) for 5 weeks in conjugation with physical training increased their performance time by approx. 70% compared to their non-drugged counterparts. Moreover, it was shown that GW501516 enhanced the influence of exercise on the whole body (5).
However, the results of studies with AICAR, the analogue of adenosine monophosphate, were far more striking. After 4 weeks of AICAR application (500 mg/kg/d) the sedentary mice were running by 23% faster and by 44% further than untreated and untrained mice (5). This report confirmed former studies that had shown that 5 days of AICAR treatment may lead to the increased levels of glycogen, glucose transporter GLUT4 and mitochondrial enzymes in mice (16). Hmmm....10mg/kg of GW50 and 500MG/KG of AICAR? No human would ever use those numbers. The recommended human doses for those who want an endurance boost is 20mg a day of GW50 and 25mg a day of AICAR. From what I can find, there are no studies showing the effects of such low levels. From my personal use, I have found that GW50 greatly increased my endurance, which a side effect that I no longer dreaded doing cardio. Cardio no longer made me feel like crap afterwards (which is why so many dread it). I doubled the time I spend in a single cardio session (from 20 mins to 40 mins) and still feel more alive afterwards than before I used GW50. I have yet to use AICAR, but plan to soon. I will replace my normal GW50 use with AICAR and see how it compares.