Benefit of running T4 along side of gh

[GotClen]

TweetI have been trying to find some story's documenting the reasoning behind how T4 is a better choice when running GH. I knew I have read about it but just couldn't find anything. Then I just found this online and wanted to share. Looks like I need to stock some T4. Here you go

By Mark Stent (B.Sc, Dipl Dat, SPN)

Growth hormone and thyroid hormones have been standard drugs in the arsenals of bodybuilders for years. Growth hormone has been used for its anabolic, muscle cell increasing, fat loss and anti aging properties. Thyroid hormones have been used for the fat loss, stimulatory and (to a lesser extent) anabolic effects. In this article I will look at the synergies between the two different types of thyroid hormone (T4 and T3) and Growth hormone (GH) and their applications in bodybuilding.

Before we get into the juicy stuff, we need to start with a little ‘geek-talk’ and some physiology.

The body produces two thyroid hormones, the first is thyroxine (T4) and the second is triiodothyronine (T3), which is the most widely used thyroid hormone in the world of muscle building. T4 is the inactive thyroid hormone and needs to be converted to T3 to exert thyroid-specific effects. This is done by the enzymes in the deiodinase group, of which there are 3 types – D1 and D2, which involved in the initiation of the process of conversion of T4 to T3 and D3, which is involved in the deactivation process.

The secretion of T4 is created in the thyroid gland and is stimulated by Thyroid stimulating hormone (TSH), which in turn is stimulated by Thryrotropin Releasing hormone (TRH). So, when T3 levels rise, the body says, ‘hey, I have enough T3 floating around, so I need to cut back’, which it does by suppressing TSH (this is known as a ‘negative feedback loop’). Incidentally, thyroid hormones require insulin or IGF-1 to trigger their effects.

Growth hormone (GH) is produced in the pituitary gland and is regulated by factors such as hormones and enzymes. It is regulated by two hormones Somatostatin (SS) and Growth hormone releasing hormone (GHRH). When there is too much GH circulating the body another negative feedback loop tells it to produce SS to decrease GH levels. When the body has too little GH, GHRH is produced.

GH has the ability to stimulate the conversion of T4 to T3, making thyroid hormones partially dependent on GH. Somatostatin (which is secreted when GH levels are too high) can also inhibit TSH secretion or reduce TRH secretion, which means it can limit the amount of T4 produced by the body. This means that although GH increases the conversion of T4 to T3, which means more T3, it may actually mean lower than normal T4 levels.

GH gene transcription is what gives GH its wonderful effects (such as muscle growth, fat loss etc) and T3 enhances these effects, making GH and T3 extremely synergistic, in fact, T3 is the limiting factor in exogenous GH usage. Here we now have a contradiction: T3 and GH are synergistic, but too much T3 decreases the anabolic effects of GH.

This is where Anthony Roberts (a well known steroid and performance enhancing drugs expert) hypothesised that it is the conversion process of T4 to T3 that is important. Let me explain. When there is too much T3 in the body and normal levels of T4, the thyroid sends a signal to produce less D1 and D2 (the activators) and more of D3 (the in-activator) and thus inhibits many of the synergistic effects of T3. When D3 levels are high, growth factors such as IGF-1 are stimulated, which means D3 is an important part of the equation with regards to the anabolic effects of GH.

Now for the part you have all been waiting for, the summary and conclusion…

When growth hormone is taken, along with T3, the GH will stop converting T4 to T3 after a certain point, which means it will shut of the good, anabolic effects of GH by killing the pathway that creates them! This, to me, seems like a bad thing! Now if we add T4 into a GH cycle, we would enhance this pathway, giving the GH more anabolic effects!

Remember that T4 alone is pretty ineffective for our purposes and requires something like GH to be made effective.

I have actually seen how effective using T4 in conjunction with GH is, first hand. An athlete I was working with was dieting for a show using GH and T3 (along with many other anabolic compounds), but was seeing no change in his fat to muscle ratio. Even with changes in his diet, such as lowering carbs, increasing cardio and even lowering calories, there were minimal changes, at best. T4 was introduced and within 1 week a change of 2.5% body fat and an increase of 1kg of muscle was measured! This is a pretty drastic change in any book.

The way I see it, growth hormone costs a lot, and, if it were me, I would want to maximise it as much as possible to get a better ‘bang for my buck’, T4 seems to be the catalyst here and without it, GH is a waste of money.

[alluprbdy]

TweetDon't get me wrong I like T4 however I like T3 just as much. I honestly have never noticed much of a difference outside of the kick in time. T3 starts working a lot quicker however downside with it is if you left for a 3 day weekend vacay and forgot your pills you will notice that come day 2-3. t3 has a very short half life, about a day. This is my only reason I use T4 more often than T3 b/c I have a vacation home and I do a lot of 3-4 day weekends and my memory can suck at times. I personally never ran GH without thyroid meds so I can't give any input on the whole lowering of your levels and efing with your metabolism however I can say none of my friends are willing to **** with their thyroids (prob not a "bad" idea, lol) and none of them have ever had any issues with thyroid on GH and they run some pretty high doses at times of Growth. I couldn't disagree more with the article with the following,

"Remember that T4 alone is pretty ineffective for our purposes and requires something like GH to be made effective."

Nah no way, I personally think totally opposite and imo t3/t4 is the absolute best bang for the buck supplement I use besides Test E. It works great without HGH, and in fact I recommend it to a lot of potential growth users who are using it b/c they heard how great it is for fat loss (which as I'm sure a lot on here realize its okay for fat loss, but there are far better and more affordable choices for fat loss than growth) and I turn them onto to T3/4 b/c it is that "magic pill" for a lot of people that don't have the ability to discipline themselves in a cutting diet. It works amazingly well, and just FYI Anthony Roberts is a fraud and con man and just a total pos who tried taking down the Research market a few years back so just gotta get my **** Him in,

My only concerns for t3/4 use with GH are:

1. If trying to put on weight its very counter productive
2. Don't stay on it too long, its not something you want to **** up.

Outside of that I love it, and I've used it a lot with and without GH.

[Arx International]

TweetIve used t/3,t/4 for years with great results....Usual doses are at 100mcg ed...Always usually cycle these
products every 6weeks!
I usually use t/3 1st and end with t/4,clen....Im sure there is medical philosophy jargon to properly back
up the proper way to use the product,but trial and error have worked for me....