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Science shines light on the fact that the different forms of estrogen have a profoundly different risk profile for breast cancer. It has been known for years that E2 (estradiol), the form of estrogen associated with the menstrual cycle, can—especially in combination with other metabolic malfunction—cause breast cancer. Research shows that E3 (estriol) has the opposite effect, actually blocking the breast cancer gene signals activated by E2. This finding is of major significance for any woman seeking strategies to help reduce breast cancer risk.
Molecular science demonstrated that estradiol’s activation of estrogen receptors increased the risk for breast cancer. More recent gene science shows that estradiol activates something called G protein-coupled receptor 301 (GPR30), which turns on growth in a variety of female cancers. This study shows that estriol directly blocks activation of GPR302, in turn preventing activation of a variety of genes fueling breast cancer growth. It has long been observed that estriol appeared protective against female cancers – here is the first proof of the mechanism.
Many women suffer from high estradiol. Symptoms include heavy menstrual cycles and headaches with the menstrual cycle. Stress and digestive problems aggravate these issues. A woman in her early forties often has increased estradiol production prior to menopause (again reflected by heavier cycles). Any of these factors fuel estrogen-driven cancer risk. While any women with symptoms of high-estrogen menstrual cycles should work diligently to improve the underlying health problems causing this issue, it appears that estriol is protective and could be used along with progesterone to promote a healthier balance between these important female hormones.
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Molecular science demonstrated that estradiol’s activation of estrogen receptors increased the risk for breast cancer. More recent gene science shows that estradiol activates something called G protein-coupled receptor 301 (GPR30), which turns on growth in a variety of female cancers. This study shows that estriol directly blocks activation of GPR302, in turn preventing activation of a variety of genes fueling breast cancer growth. It has long been observed that estriol appeared protective against female cancers – here is the first proof of the mechanism.
Many women suffer from high estradiol. Symptoms include heavy menstrual cycles and headaches with the menstrual cycle. Stress and digestive problems aggravate these issues. A woman in her early forties often has increased estradiol production prior to menopause (again reflected by heavier cycles). Any of these factors fuel estrogen-driven cancer risk. While any women with symptoms of high-estrogen menstrual cycles should work diligently to improve the underlying health problems causing this issue, it appears that estriol is protective and could be used along with progesterone to promote a healthier balance between these important female hormones.
More...