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    Thread: Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism

    1. #1
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      Default Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism



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      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism

      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism J Clin Invest. 1995

      Oct;96(4):1722-9. Related Articles, Links

      Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms.

      Fryburg DA, Jahn LA, Hill SA, Oliveras DM, Barrett EJ.

      Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.

      Insulin inhibits proteolysis in human muscle thereby increasing protein anabolism. In contrast, IGF-I promotes muscle protein anabolism principally by stimulating protein synthesis. As increases or decreases of plasma amino acids may affect protein turnover in muscle and also alter the muscle's response to insulin and/or IGF-I, this study was designed to examine the effects of insulin and IGF-I on human muscle protein turnover during hyperaminoacidemia. We measured phenylalanine balance and [3H]-phenylalanine kinetics in both forearms of 22 postabsorptive adults during a continuous [3H] phenylalanine infusion. Measurements were made basally and at 3 and 6 h after beginning a systemic infusion of a balanced amino acid mixture that raised arterial phenylalanine concentration about twofold. Throughout the 6 h, 10 subjects received insulin locally (0.035 mU/min per kg) into one brachial artery while 12 other subjects were given intraaterial IGF-I (100 ng/min per kg) to raise insulin or IGF-I concentrations, respectively, in the infused arm. The contralateral arm in each study served as a simultaneous control for the effects of amino acids (aa) alone. Glucose uptake and lactate release increased in the insulin- and IGF-I-infused forearms (P < 0.01) but did not change in the contralateral (aa alone) forearm in either study. In the aa alone arm in both studies, hyperaminoacidemia reversed the postabsorptive net phenylalanine release by muscle to a net uptake (P < 0.025, for each) due to a stimulation of muscle protein synthesis. In the hormone-infused arms, the addition of either insulin or IGF-I promoted greater positive shifts in phenylalanine balance than the aa alone arm (P < 0.01). With insulin, the enhanced anabolism was due to inhibition of protein degradation (P < 0.02), whereas IGF-I augmented anabolism by a further stimulation of protein synthesis above aa alone (P < 0.02). We conclude that: (a) hyperaminoacidemia specifically stimulates muscle protein synthesis; ( insulin, even with hyperaminoacidemia, improves muscle protein balance solely by inhibiting proteolysis; and © hyperaminoacidemia combined with IGF-I enhances protein synthesis more than either alone.
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      Default Re: Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism

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      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism

      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      • Insulin vs. IGF-1 Their Respective Effects on Anabolism/Catabolism
      aminoaciduria (ami&#183;no&#183;ac&#183;id&#183;u&#183;ria) (ə-me”no-as”ĭ-du&#180;re-ə) an excess of amino acids in the urine; many types are called by the name of the amino acid plus the suffix -uria, such as cystinuria, lysinuria, and tryptophanuria. Called also hyperaminoaciduria.

      overflow a. that caused by excessive levels of a given amino acid in the blood.

      renal a. that caused by defective transport mechanisms for amino acids in the renal tubules.

      ---
      proteolysis (pro&#183;te&#183;ol&#183;y&#183;sis) (pro”te-ol&#180;ĭ-sis) [protein + -lysis] the splitting of proteins by hydrolysis of the peptide bonds with formation of smaller polypeptides; the process may be catalyzed by proteolytic enzymes, by acids, or by bases.


      "We conclude that: (a) lots of protien intake specifically stimulates muscle protein building; ( insulin, even with lots of protein, improves muscle protein balance solely inhibiting proteolysis; and &#169; hyperaminoacidemia combined with IGF-I enhances protein synthesis more than either alone."

      so slin is better than nothing and IGF-1 is better than slin. But slin is drit cheap and IGF is very costly.

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