Tweeti haven't taken time off in 5 years other than the occasional week or so here and there. I choose to blast and cruise(alternate periods of higher doses and lower doses) because I already have a child(who was conceived 2years into a cycle) so i'm not worried about sterility. actually to be honest the sterility thing was the only thing holding me back before. Most other side effects ae temporary or can be corrected if watched careful enough. I do know my bp runs a little high during my blasts, its usually in the 140 range, but cholesterol is usually decent as i do eat a bit of red meat and some fried food but mostly chicken and the fried food is only a treat here and there. I've also chosen to stay on because it has taken so long to get to where i am but i'm also very far(in my eyes) from my goal and i ain't getting younger(36).