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Originally Posted by lxorl

so,

Tren A.... aggrivates my small existing gyno...

i would assume i should expect the same from NPP ??

IF YOU CAN TAKE DECA OR PROP...IT SHOULDNT

TweetIF YA GOT GYNO MOST LIKELY EVERYTHINGS GOING TO AGGRAVATE IT.

TweetBROMO WILL DEAL WITH PROGESTERONE INDUCED GYNO FROM TREN...BUT LIKE FUZO SAID...BE CAREFUL IF YOUVE ALREADY GOT IT TO NOT AGGRIVATE IT WORSE

Tweetlast cycle was winny only and obviously that didnt effect any...

been debating going with winny alone again... or using test or NPP with...

Tweetnpp will for sure induce or re-establish old gyno if run too high and for too long.....i use femera with mine and works like a charm.

npp is a great product....nice addition to any cycle by the way.

TweetGet some liquid aroma from one of the sponsors, that should help.

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Originally Posted by T-Man007

Get some liquid aroma from one of the sponsors, that should help.

dont think that works for progesterone gyno..you need bromo

Tweetya....bromo for progest gyno for sure. there's a couple others bet its not worth the money when bromo works just the same.

TweetIt wouldn't hurt to throw in some Vit. B complex too with the bromo for prog. gyno.

TweetI just read something about prog gyno being non-sense.
I don't know if there's any fact to it but if I find it again I will post it.

I am a bit cautious as I am planning on adding the npp to the tren ain my current cycle and I have the tiniest amount of sore nips right now.
It is defintely going away now that I have stopped the megaload dbol dose I was on. That and I have been taking aroma religously for a while now.

I'll see if I can find the post again and maybe we can hash over it.


Sal

TweetIt was still in my favs:

I somehow came across this on "bbforums"

Post by Pheedno. Always a pleasure reading his posts...

I would like to cear up a few misconceptions about progesterone and gynecomastia.

Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window. Tren? Deca? Sorry but it just doesn't happen.

Now Tren and Deca bind pretty well to the PR. They are progestins in their own right without undergoing any structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the PR has two isoforms. The PR-A and PR-B. PR-B mediates stimulatory effects of progestins; PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is dominant,. The response to progesterone is determined by the relative expression of the two isoforms.

There is a direct relationship between the PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though

Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises IGF. Progesterone induced gyno is not really of a concern given binding affinity to the PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.

I then asked about bromo and this was his explanation. Many are not too familiar with it's actual mechanism.

bromo is a prolactin inhibitor, as it's a dopamine agonist. Dopamine regulates prolactin. Bromo, dostinex, pergolide, and alike drugs have no direct effect over progesterone

Just to add. B6 is the safest way to help control prolactin. This is recommended before taking the step to a power drug like bromo.


What are your thoughts on this everyone???

Sal

Tweet^ i dont know, pheedno usually knows his stuff, but i only get a little gyno when im on tren or deca, nothing else.

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Originally Posted by FUZO

IF YA GOT GYNO MOST LIKELY EVERYTHINGS GOING TO AGGRAVATE IT.

Exactly like Fuzo said. If tren gives you gyno then you are probably very succeptible to it. Bromo is supposedly good for use with Tren and NPP. You definately should be running nolv with all of your cycles imo. I would run 20mg ed throughout if you are that sensitive.