TweetLipid profiles are largely affected by the types of gear you use, your genetics and your diet.
I know people who get screwed fast -- and others who have stayed on cycle FOREVER and barely a blip on the radar screen.
However, that being said, it is NEVER wise to be on cycle forever. Your body just needs to detox...your joints and tendons do not gain from aas as your muscles do -- and you are just begging for an injury.
As far as keeping your profile under control, aside from breaks, keep your stacks simple, take ALA and milk thistle.
As for other suggestions, diet SUPER CLEAN and I am sure some of the other guys will come along and give you better suggestions. We women get effected not as severely as you boys do.