TweetIt is better to spread the hcg into smaller dosages, like to 1000IU twice ew, but even better is to do 500IU three times ew. To answer your question though, no one 2000IU shot will not shut you down. I did 1000IU 3 times eq during hrt and it didn't shut me down at all, it is used for atrophy and to bring up natural free test. Only way it could potentially hamper your natural test is if you continued very high dosages for many, many months non stop.