Tweetit doesn't seem too toxic to me. i have taken it only transdermally and orally tho. i love it! sides are pretty low for me, personally. i can easily put on a quick 10 lbs on this with a bulking diet, and i can cut on it too as it seems to have a thermogenic effect. i just with i had some in oil. you definitely have to watch for estrogen and cardo sides, but it's not 17aa so shouldn't be too liver toxic. it is definitely a "feel good" compound, mentally. i got night sweats/bloating and some anger/aggression when i ran it high. also watch your blood pressure. it's strong but if taken at low to modest doses side effects shouldn't be too bad or hard to handle imho.