TweetEq can sometimes be linked to anxiety. Every compound effects everyone differently. Are you sleeping well. Anxiety will wreak havok on your body. I'd try adjusting your doses and see if things alleviate. There may be other factors at play so you gotta start with the one thing that's new to you..the eq. I personally haven't heard of depression being a side of any compound. But anxiety will take away your appetite, make you feel fatigued. Im not sure if that's the issue, but I'd start with adjusting that eq dosage.