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Something just happened to me. Went to doctor and the blood test said I had enzyme level that I should watch. So I got all the liver support that Mr. Supp has and started taking them. After about a month I had acid reflux and the hic-ups nonstop for 10 days. I stopped taking the liver support and was all better in three days. Moral of the story is if you are taking liver support during your run it may be causing the problem.