Femara and test

[JohnnyB]

Here's something I found on femara. It could help in post cycle test recovery.

Aromatase inhibitors in men

The effect of aromatase inhibition on male gonadotrophin and sex steroid concentrations is illustrated in the paper by Trunet et al. (1993): 2.5 mg letrozole suppressed plasma oestradiol concentrations to less than 50% of pretreatment after 2 days, with recovery to approximately pretreatment values after 6 days. These decreases were accompanied by increased gonadotrophin concentrations, with resultant increases of approximately 50% in plasma testosterone. These results, and those previously published (Bhatnagar et al. 1992) on the effects of fadrozole in men, indicate that the aromatization pathway is of major importance in the regulation of gonodotrophin secretion by aromatically androgens.

Full text of this article can be downloaded in PDF format.

http://journals.endocrinology.org/e.../erc0060181.htm

JohnnyB

[StoneColdNTO]

Interesting, btw....the link doesn't work

[JohnnyB]

I just hit it and it worked, give it another try, Bro

JohnnyB

[Billy_Bathgate]

Aromasin is far superior. Femera is a bad choice IMO.


Clin Breast Cancer 2000 Sep;1 Suppl 1:S68-73

Comparison of in vitro exemestane activity versus other antiaromatase agents.

Soudon J.

Anastrozole, letrozole, and exemestane are the most selective and potent oral antiaromatase agents currently available. However, in vitro and in vivo studies comparing these agents are lacking. Anastrozole and letrozole are reversible, competitive nonsteroidal type II inhibitors, whereas exemestane is an irreversible steroidal type I inactivator. The study was conducted to determine the impact of this characteristic on in vitro residual aromatase activity and protein levels after incubation of JEG-3 cells with aminoglutethimide (a type II inhibitor), anastrozole, exemestane, or letrozole. Aromatase activity was measured after various incubation times with each antiaromatase agent at a concentration 10 times higher than IC50 (concentration giving 50% inhibition). Only exemestane induced a residual inhibition of aromatase activity after its removal, without any change in the aromatase protein level.

Aromatase activity increased after preincubation of JEG-3 cells with either aminoglutethimide or anastrozole without any change in the aromatase protein level.

The aromatase protein level increased rapidly when cells were incubated with letrozole and aromatase activity inhibition disappeared immediately after removal of the drug.

The breakthrough effects in aromatase activity or protein levels observed after treatment with reversible inhibitors may be a factor in therapeutic failure with these agents. These results suggest a possible advantage for exemestane because it is the only clinically available oral irreversible aromatase inactivator.

Meaning, if you do use Femera (letrozole), you had better follow it up with Ari (anastrozole) or even better Aromasin (exemestane).

[Lift Chief]

Femara is still better than Arimidex though as far as i know. Aromasin is just the best.

[JohnnyB]

Billy the study is based on in vitro use not oral administration

JohnnyB

[Billy_Bathgate]

Correct, but that wouldnt change the biomechanics of it.

[Saint7]

Quick question how is aromasin the best? Is it a anti e or a site blocker? Saint7

[Billy_Bathgate]

Originally posted by Saint7
Quick question how is aromasin the best? Is it a anti e or a site blocker? Saint7

From the study I just posted "exemestane because it is the only clinically available oral irreversible aromatase inactivator."

Its an anti-e...a permanent one.

[Billy_Bathgate]

Originally posted by Cirrus2000
bump for more answers....Bouncer ?

I was going to use Femera during my cycle.....is that a no-no ?

IMO no its fine to use but I would suggest following it up with ari, aro, even prov clomid or nolva before discontinuing it though. A follow up for 2-3 wks would be plenty at that. If nothing else, just keep it in mind and keep your eye open for high estrogen signs after discontinuation of femera.

[jack hust]

interesting

[goliath.jr]

Femara is very hard on the lipid profile. Aromasin is easy on the lipid profile. It also blocks up to 95% of aromatisation wheras Arimidex only blocks up to 75%. Aromasin is by far the best choice if you can find it.

[hhajdo]

Originally posted by goliath.jr
Femara is very hard on the lipid profile. Aromasin is easy on the lipid profile. It also blocks up to 95% of aromatisation wheras Arimidex only blocks up to 75%. Aromasin is by far the best choice if you can find it.

That's only true in postmenopausal women.
E suppression in men induced by aromatase inhibitors is usually 50-60 %.

[JohnnyB]

Originally posted by StoneColdNTO
Interesting, btw....the link doesn't work

I was going to go with femara to help my test, but when the Doc said he give me a scrip for test, I went for the test.

JohnnyB

[hhajdo]

Originally posted by StoneColdNTO
Interesting, btw....the link doesn't work

http://journals.endocrinology.org/erc/006/0181/0060181.pdf